Scientific Director – ADME in Indianapolis

Job Description

Join American pharmaceutical leader Eli Lilly and Company, currently hiring Scientific Director – ADME in Indianapolis, Apply Lilly careers in Indianapolis Indiana.


Position : Scientific Director – ADME

Location : Indianapolis, Indiana

Job id: R-32088


Job Details

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.We are growing! Lilly is on the forefront of cutting-edge research and has established the Lilly Institute of New Genetics Medicine. The Biotechnology Research/ADME-PK group is looking for scientists interested in pioneering novel drug modalities to join us in this effort. We seek dynamic, energetic, collaborative scientists to work on life-changing therapies for patients involving novel complex molecules including DNA and RNA-based technologies. You will have the opportunity to engage with diverse teams in a ‘biotech-like’ manner within the walls of Lilly where innovative ways of thinking are essential to advance these innovative platforms. To meet this changing environment, we are expanding our teams in Indianapolis and Boston to enable strong cross functional teamwork.The Biotechnology Research/ADME group is responsible for evaluating the preclinical pharmacokineticsand disposition of complex molecules including gene therapies, siRNA, therapeutic proteins/peptides and monoclonal antibodies. Our diverse team interfaces with toxicology, discovery biology, protein engineering and multiple therapeutic areas to help identify and characterize optimal therapeutic candidates to advance through clinical testing. The group is expanding capabilities in analytical, cell biology and PK/PD to more fully characterize factors influencing the absorption and disposition of biologic therapeutics so we are looking for candidates with diverse skill sets including experience in molecular biology, siRNA, immunochemistry, gene editing, and clinical development.Position Description:Individual scientific contributor to function as an ADME subject matter expert in multidisciplinary team environments with primary responsibility for the early preclinical development of innovative molecules (siRNA, antibodies, fusion proteins, drug conjugates)Integrate pharmacokinetics and PK/PD with discovery biology to define structure activity relationships to guide engineering strategies and help optimize development of protein and genetic therapeuticsInteract across groups, including other departments, regulatory agencies, and functional teams within drug dispositionResponsible for the design, conduct, interpretation and reporting of study resultsContribute to strategic workflows to streamline molecule selection and evaluationExperienced with ADME development phase support, including preparation of regulatory briefing documents, IND, investigator brochures, non-clinical and clinical study protocols, and study reporting.Basic Qualifications:
Ph.D. in Pharmacology, Biochemistry, Molecular Biology, Pharmaceutical Sciences, or a related field with 5+ years of experience in the industrial discovery and development of biological-therapeutics.Additional Skills/Preferences:Industry (Pharma/Biotech) experience in the preclinical evaluation of biologics and/or hybrid modalitiesExperience working with oligonucleotide-based therapeuticsPrior experience working in an interdisciplinary teamStrong scientific and analytical skills.An understanding and/or experience with immunoassay and/or LC/MS bioanalytical methodologyDemonstrated ability to multitask efficiently, prioritize quickly and bring projects to conclusion.Experience working in a matrixed work environmentHave a track record of leadership of scientific rigor and excellence.Excellent oral and written skills.The ideal candidate will have demonstrated ability to identify scientific issues and solve problems, both individually and with partners in functional groupsEli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).



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